Granulation - Flexible process, either in a high shear granulator or a fluid bed system
TYPES OF GRANULATION
- Wet (high / low shear mixers, fluid bed granulation, spray drying granulation)
- Thermoplastic (melt granulation)
The High Shear granulation process is a fast homogeneous combination of active powder and excipients with a binder solution or wetting agent using a high-intensity mixing blade.
- Mixing of dry ingredients
- Liquid Addition
- Wet Granulation
Continuous High Shear Granulation
- De-agglomeration of pre-blended powders
- Liquid Addition and Granulation
The Spray Granulation Process
Fluid bed granulation / agglomeration methods have been used for many years especially within the pharmaceutical industry. The same product container is used as for fluid bed drying with a spray nozzle assembly fitted above the product bed. The process has three stages:
- Mixing of the dry ingredients
- Liquid addition and granulation
- Drying of the granule
The top spray granulator agglomerates finer particles into larger, free flowing granulates in a one-pot process. Ingredients are mixed and pre-heated by an upward flow of heated air. The granulation process occurs by spraying liquid into the fluidized powder. The granules are subsequently dried with heated air. The top spray granulator can also be used for top spray coating, layering from liquids, and instantizing.
Spray Dryer Granulator
The spray dryer granulator transforms suspensions or solutions into dry, free-flowing, dustless granules. A suspension or solution of the substance to be dried is sprayed onto warm air, simultaneously drying and agglomerating the product. Batch or continuous discharge is available in the continuous mode, and the product is discharged at a controlled rate to maintain an optimum bed height.
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