The GEA Niro Pharma Test Station includes two fully equipped GEA Niro PHARMASD™ spray dryers type PSD-1 and PSD- 4 for spray drying under cGMP conditions. The plants are available for spray drying process development and for manufacturing. Read the brochure on our Pharmaceutical Test Station and the brochure on pharmaceutical spray drying.
Click here to see a full-screen version of the flow-sheet.
Plant configuration
- Main components: Chamber, cyclone, bag filter, HEPA-filters, condenser, electrical heaters
- Nitrogen as drying gas
- Closed-cycle loop
- Powder collection under cyclone. Bag filter for collecting fines
- Atomization methods:
- Pressure nozzle, co-current
- Two-fluid nozzle, co-current
Feed
- Mixing of various solvents possible
- Dosing and mixing of various raw materials possible
- Filtration of feed possible
Solvents
- Water
- Ethanol
- Methanol
- Isopropyl alcohol
- Acetone
- Methylene chloride
- Ethyl acetate
Operating parameters
| Inlet temperature |
up to 220 °C |
| Outlet temperature |
up to 150 °C |
| Condenser temperature |
down to -18 °C |
| Feed temperature |
5 °C to 80 °C |
| Pressure nozzle, atomization pressure |
10 bar to 100 bar |
| Two-fluid nozzle, gas pressure |
0,5 bar to 14 bar |
| Two-fl uid nozzle, atomization gas temperature |
18 °C to 100 °C |
CIP
| CIP liquid temperature: |
Up to 80 °C |
Capacity
The PSD-1 spray dryer is a lab size unit with a nominal drying gas rate of 80 kg./h. The PSD-4 spray dryer is the a full scale production unit with a nominal drying gas rate of 1250 kg./h.
Click here to see a full-screen version of the capacity graph.