Aseptic spray drying offers a number of advantages over traditional methods of aseptic drying such as lyophilisation. More specifically, by allowing precise control of the drying process, spray drying gives far greater command over the shape, density and morphology of the final product. What’s more, with lower running and capital costs, these advantages are obtained while reducing overheads.
Production of dry sterile dosage forms often involves mixing of the API with one or more excipients. To achieve a homogeneous mixture, the particle size distribution of the excipient(s) must match that of the API. In a one-step-operation, spray drying can turn a sterile solution into sterile particles of the required size with no risk of introducing impurities - a well-known problem if milling is used.